Matrix Metalloproteinases in Acute Intracerebral Hemorrhage
نویسندگان
چکیده
منابع مشابه
Matrix metalloproteinases in human spontaneous intracerebral hemorrhage: an update.
BACKGROUND In default of a plausible and satisfactory causal treatment for hemorrhagic stroke, a role of matrix metalloproteinases (MMPs) in the pathogenesis of cerebrovascular diseases has recently been widely discussed. The well-known impact of MMPs on extracellular matrix destruction triggered by inflammation as a foundation for several diseases, including stroke, is very much in evidence. N...
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Intracerebral hemorrhage (ICH) is characterized by parenchymal hematoma formation with surrounding inflammation. Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of neurological diseases defined by inflammation and cell death. To investigate the expression profile and pathogenic aspects of MMPs in ICH, we examined MMP expression in vivo using a collagenase-induced rat m...
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BACKGROUND AND PURPOSE Cerebral autoregulation (CA) is not universally impaired in acute intracerebral hemorrhage (ICH); however, the dynamic components of CA are probably more vulnerable. This study, therefore, evaluates the time course of dynamic CA in acute ICH and its relationship to clinical outcome. METHODS Twenty-six patients with ICH were studied on days 1, 3, and 5 after ictus. Dynam...
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One of the most serious forms of stroke is intracerebral hemorrhage (ICH) as fewer than 30 % of patients recover to functional independence and the one-year mortality rate of over 50 % is very high [1–3]. In hemorrhagic stroke, oral anticoagulation-associated intracerebral hemorrhage (OAC-ICH) is of particular concern because it is associated with larger hemorrhage volumes, increased ventricula...
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Spontaneous ICH is a devastating condition and is associated with significant mortality in the acute phase due to ongoing hemorrhage and hematoma expansion. A growing body of evidence suggests that there may be considerable utility in performing noninvasive vascular imaging during the acute-to-early phase of ICH. CTA has become widely available and is sensitive and specific for detecting vascul...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2020
ISSN: 1933-7213,1878-7479
DOI: 10.1007/s13311-020-00839-0